Pair Name	Lycopene, Enzalutamide
Disease Info	[ICD-11: 2C82.0]	Prostate cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	EZH2	hsa2146
	Down-regulation	Expression	AR	hsa367
	Down-regulation	Expression	MMP2	hsa4313
	Down-regulation	Expression	MMP9	hsa4318
	Down-regulation	Expression	PCNA	hsa5111
In Vitro Model	LNCaP C4-2B	Prostate carcinoma	Homo sapiens (Human)	CVCL_4784
	22Rv1	Prostate carcinoma	Homo sapiens (Human)	CVCL_1045
In Vivo Model	22RV1 cells (2×10⁶) were injected into left tibia or the right flank of nude mice.
Result	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.